JAAPA CME Post-Test January 2025
Recognition and Management of Treatment-Resistant Depression
Major depressive disorder (MDD) is a common psychiatric condition that causes considerable morbidity and disability. MDD is characterized by recurrent depressive episodes that can result in loss of productivity, job insecurity, social isolation, and suicidality. Primary care providers frequently
provide the initial management of MDD; however, some patients do not respond to first- or second-line treatments, a condition called treatment-resistant depression (TRD). Understanding how to accurately diagnose and manage TRD is important for clinicians.
Learning Objectives
At the conclusion of this activity, participants should be able to:- Define treatment-resistant depression
- Understand treatment-resistant depression as a subset of the population of patients with major depressive disorder
- Understand the diminishing likelihood of response/remission with each failed course of treatment
- Recognize appropriate next steps in management beyond first-line pharmacotherapy
Wilms Tumor and Associated Predisposing Syndromes and Conditions
Wilms tumor, also known as nephroblastoma, is relatively rare but is the most common renal malignancy in children, accounting for about 5% of all childhood malignancies
and 90% of all childhood renal malignancies. Advances in the understanding of the underlying cause and pathophysiology of Wilms tumor have significantly improved the prognosis and survival rates for children with Wilms tumor, but cases may occur sporadically and certain affected patients face higher rates of relapse and morbidity. The most common clinical presentation involves the identification of an abdominal mass or swelling without other signs or symptoms. The nonspecific nature of symptoms that can present can delay timely diagnosis and treatment. Numerous predisposing syndromes are associated with an increased risk for the development of Wilms tumor. Clinicians who recognize these syndromes and other conditions and understand the increased risk can provide the appropriate level of anticipatory guidance and use the optimal screening plan.
Learning Objectives
At the conclusion of this activity, participants should be able to:- Describe the epidemiologic burden of pediatric cancer and Wilms tumor
- Identify the risk factors and predisposing syndromes associated with Wilms tumor
- List the appropriate screening precautions required for predisposing syndromes associated with Wilms tumor
- Describe the common clinical presentation and diagnostic steps for a patient with Wilms tumor
AAPA offers no returns or refunds for online CME activities purchased via the AAPA store. All sales are final.