COVID-19: Considerations of Viral Replication and Testing

While the early and uncertain stages of the COVID-19 pandemic have subsided, we now enter a phase of increasing vaccinations and deeper learning about effective treatment. These preventative measures and treatments for active infection are essential to staunch further mutations of the coronavirus. In speaking with physicians and reviewing the emerging literature, several gaps in knowledge for diagnosing and treating COVID-19 still exist. These encompass (1) the initial stages of disease and knowledge of the viral lifecycle, which impact diagnostic testing, (2) patient characteristics and co-morbidities that put patients with COVID-19 at greater risk for poor outcomes, (3) the short- and long-term impact of post-COVID-19 sequelae, and (4) the management and treatment of COVID-19 infection. Through this educational initiative, clinicians will cover these topics and gain a deeper understanding of the SARS-CoV-2 virus and to clarify their pivotal role in diagnosing and managing patients with COVID-19.

This educational initiative provides an understanding of SARS-CoV-2 virus lifecycle and clarifies the pivotal role of timely diagnosis and management. This is module 1 of a 3-part module series.

Learning Objectives


At the conclusion of this activity, participants should be able to:

  • Apply understanding of the impact of COVID-19 both on patients and to the healthcare system broadly
  • Incorporate knowledge of SARS-CoV-2 lifecycle and host responses, to the diagnosis of patients with COVID-19
  • Use knowledge of key COVID-19 co-morbidities and patient-specific characteristics that affect associated morbidity and mortality to better manage these patients
  • Manage and prevent the short and long-term complications of COVID-19 more effectively

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Acknowledgement of Commercial Support


This activity is supported by an independent educational grant from Pfizer.