Post-COVID conditions (commonly known as Long COVID or post-acute sequelae of COVID-19 [PASC]) refer to a constellation of new, returning, or persistent health problems experienced at least 3 months after an initial SARS-CoV-2 infection that last for at least 2 months and cannot be explained by alternative diagnoses. Long COVID is a multisystem chronic condition: it can involve nearly any organ system and present with a wide array of symptoms, ranging from fatigue, cognitive dysfunction (“brain fog”), and dyspnea to chest pain, palpitations, or neuropsychiatric effects. Long COVID can cause significant functional impairment and even meet criteria for disability in many cases. The landscape of Long COVID research and clinical guidance is evolving at a rapid pace. Primary care and infectious disease providers should stay attuned to new developments, as today’s uncertainties may yield to tomorrow’s breakthroughs.

Learning Objectives

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At the conclusion of this activity, participants should be able to:

• Apply current clinical definitions, structured history‐taking, and risk-stratification data to differentiate post-COVID conditions from alternative diagnoses
• Implement individualized, multimodal management plans that integrate evidence-based therapies, rehabilitation strategies, timely referrals, and structured follow-up
• Integrate culturally responsive communication techniques and community resource navigation to ensure equitable assessment and management of post-COVID conditions across diverse populations
• Critically evaluate and synthesize emerging research to facilitate appropriate recommendations for prevention, assessment, and treatment of post-COVID conditions
  

Acknowledgment of Commercial Support

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This activity is supported by an educational grant from Pfizer, Inc.